Episode 34. Making penicillin (1)
“Keuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuuu!
The painter, who got up from the bed, shook his head while forcibly moving his body.
Yesterday, after sparring with my brother until he collapsed from exhaustion, he fell asleep without even eating dinner, and now he woke up.
“Haa~ I tried desperately to attack with all my strength, but I couldn’t even get a single shot right.”
Dalian did not think of his opponent as his brother, but as a bandit trying to kill himself, and did his best with desperate determination, but it was a high and solid mountain that his brother could not climb.
The fireman ignored the screaming muscles and began to warm up.
The way he warmed up his body was a modern medical stretching method that was a little different from what his older brother had taught him.
Han Jin-soo was also in the Department of Rehabilitation Medicine during his internship, so he knew all the ways to solve hardened or stiff parts.
Whoop whoop…..
Not even 5 minutes after I started warming up, my breathing became rough.
After a while, sweat began to flow from his face, while the clamor of his screaming muscles significantly diminished.
‘Haa~ I think I’ll live a little longer.’
Hwabu warmed up for about 30 minutes and only stopped stretching after being drenched in sweat.
“Hmm, it’s cooler than I thought. At this rate, I don’t have to wait until dinner, so I can challenge my brother later.”
If I was in a much lighter state now, it seemed that better results would come out than yesterday.
The painter went to the backyard after eating.
My older brother was also training martial arts there.
“uh! You woke up so early.”
“yes.”
“did you eat?”
“Yes, I ate a little while ago.”
“Then are you going to the slums now?”
“No, I’m going to go to the slums for a while and before that, I’m going to have a fight with my brother.”
“Are you already with me? You must still feel sore?”
“It’s sore. It’s brisk.”
When the painter held a wooden sword and swung it into the air, a smile appeared on the flower pot’s face.
“Haha, if I’m going to play, it’s me. It’s not much fun cutting through the air alone.”
“Today will be different from yesterday.”
“Please look at me differently. Come on, relax.”
“yes.”
As the painter began to practice with a wooden sword, the flower pot peeked sideways as he practiced.
shhh! Hiss!
‘uh! what? It’s not normal, but it’s much faster and sharper than yesterday. What happened?’
The pot stopped squinting and watched the fireman’s movements for a while.
‘Then the momentum has changed again. How can you grow so much in just one day?’
It seemed that today’s Dalian would be more intense and interesting than yesterday.
* * *
The fireman ran to Sochon in the afternoon after the morning sparring. Hwa-bok, the older brother, clicked his tongue every time he saw him, but Hwa-bu greeted him with a bright smile.
The painter’s biggest concern these days was cheese.
Cheese with blue mold.
While thinking about how to make cheese with blue mold, the painter found out that there was a yogurt-like food called Naerak (奶酪).
Naerak was born when a small number of nomadic tribes began to eat milk that thickened over time by putting milk in the stomachs of sheep.
Hardened naerak is called geonrak, and Western cheese was this geonrak.
The fireman had been waiting for the blue mold to bloom by leaving the fields in an airy shade for several days.
“Maybe there was mold today?”
After leaving it in the shade for a few days, the moisture in the inner layer was lost and the case became dry.
The fireman took one of the gunraks and cut it in half.
“Ho! Little by little the blue mold started to bloom. It is a success.”
If this state is maintained for a few more days, the cases will be filled with green mold.
While the painter was looking at Gunrak with a slightly curious expression, Obo approached and made an expression that he did not understand.
“Mr.”
“why?”
“I can understand why you hardened the naerak and made it into casein, but why did you leave it to the point where it molded without even eating it?”
In the eyes of Obo, the fireman’s act was to throw away precious food that was too wasteful to eat.
“It looks a little reluctant to see green mold, but it is very good for the body. Would you like to eat?”
The painter smiled and asked.
I don’t know, but in a thousand years or so, the technology that started here will save tens of millions of people around the world every year.
“Ugh, no matter how hungry I am, I don’t eat moldy food.”
Obo waved his hand, but the painter took a part of the gunak as if he was going to force it.
“Eat it.”
“Please eat, Senator.”
When Obo freaked out and withdrew, the painter calmly ate the green moldy caseload.
“Because it’s really good for the body. Yum yum…..”
‘Ugh, it tastes sour and coppery, earthy. It really doesn’t taste very good.’
Even in modern times, I didn’t enjoy cheese.
The things I ate occasionally were also less fermented, but not to this extent, so the taste was really unfamiliar.
When the painter put the Naerak in his mouth and swallowed it without spitting it out, Ohbo made a confused expression as if he had seen something he couldn’t see.
“Are you really eating me?”
“Then do you really eat it or fake it?”
“Why are you eating it?”
“Eat because it’s good for you. Come and eat.”
“Can I not eat it?”
“If you want to live long, eat unconditionally.”
When the painter gestured with a green moldy case, Obo had no choice but to approach it, although he expressed his displeasure.
“Come on, eat. If it was bad for the body, would I have eaten it? It tastes a little strange, but you must eat it.”
The painter held out a piece of gunak in front of Obo’s mouth and waited while talking until he ate it.
“Keugh ugh!”
In the end, Ohbo accepted my request and soon frowned.
“If you spit it out, you die. It’s a layoff.”
Obo closed his eyes tightly and swallowed when the painter shouted.
“Uuk, it tastes so good I want to vomit.”
“It’s tasteless, but thanks to that, you’ve become a little healthier.”
After a while, the fireman cut other gunraks as well.
Some had green mold and some didn’t.
‘I’ll have to extract the penicillin when it’s full of green mold.’
Penicillin is also used to treat tetanus, but it was an antibiotic that could treat numerous diseases such as syphilis, scarlet fever, pneumonia, and gangrene.
It couldn’t be made in the form of a hard pill like in modern times, but it could be made in a liquid state.
The fireman’s head contained such knowledge.
‘It will take a few more days for the green mold to bloom completely, so I’ll have to prepare to extract and concentrate penicillin in the meantime.’
“Look.”
“Yes, Senator.”
“Let’s go to Author Street to buy some stuff with me.”
“Do you have a lot to buy?”
“huh. A little too much.”
“All right.”
The painter took Obo to Chohyeon’s low street and bought liquid oil, which is often used for frying, pottery bowls with holes in the bottom, and several sheets of cotton cloth.
“What are you trying to do with these?”
When Obo made a curious expression, the fireman thought about something and laughed.
“I was thinking of concentrating the fungi you hate a little more.”
“Kek! Congressman. Why is that…”
“Why! I said earlier that it’s good for your body. I do it to feed you.”
“Aww!”
Obo screamed with a really startled look on his face.
“It’s a joke, you kidding.”
The painter playfully hugged Obo by the neck.
‘No matter how much I think about it, only I should know how to make penicillin.’
The painter was eating his heart like that. In fact, there is not much difficulty in extracting it. However, if this technology becomes known, it may really have too much of an impact on changing the world.
Antibiotics and antibiotic-resistant strains of bacteria and stronger antibiotics and more modified bacteria.
The medicine of the future is starting to reduce the use of antibiotics because of the ever-upgrading risk of bacteria.
The painter looked up at the sky and pointed.
‘I gave money like that and sent the world like that! I really can’t do anything to twist the world!’
Either way, it’s not an easy thing to do.
It is true that green mold is obviously good for the body, but it is difficult to say that it has great medicinal effects by itself.
In particular, it cannot cure diseases such as tetanus.
For penicillin to kill tetanus, it must pass through the stomach and duodenum in a concentrated state and be absorbed in the small intestine.
Here comes the essence of technology once again.
The painter knew how to make the concentrated penicillin go intact to the small intestine and be absorbed.
capsule.
Pig intestines are thinned to make capsules, and penicillin concentrate is put into them.
Then, it becomes a medicine that can cure diseases such as tetanus and pneumonia, which kill a lot of people in this era.
Of course, it would be much more effective if penicillin concentrate was injected directly into the blood vessel, but it did not seem possible to make it with the current technology.
‘First of all, let’s make a little and find someone who has tetanus and conduct a clinical trial.’
The fireman looked at the misinformation after going through the knowledge in his head once more.
The two arrived at the entrance of Sochon before they knew it.
“Look.”
“why?”
“Move to Jim’s room, get some oak, and I’ll give you money, so buy a chicken.”
“oh! Are you eating chicken today?”
“Yes, I need charcoal powder from burnt oak trees, so let’s boil a chicken with that fire.”
“All right.”
After a while, when the fireman gave the money, Obo ran out excitedly.
* * *
A few days later, when the green mold was full of mold, the painter ordered Oh Bo to boil sweet potatoes and potatoes in rice water and mash them.
It is a culture medium for culturing blue mold.
Then, finely chopped cases with blue mold were spread evenly in the culture medium.
After another few days, the culture was full of green mold.
The painter placed a cotton cloth on a pottery with a hole and poured the culture solution to purify it.
Then, the liquid oil collected from the low distance was added to the refined culture medium, stirred for a long time, and then the oil floating on the water was discarded, and only the refined culture medium below was collected and poured into a charcoal powder jar.
Of course, the charcoal powder had already been washed once with distilled water and dried.
There was also a hole in the bottom of the charcoal powder jar, and a cotton cloth was supporting the hole.
The painter poured distilled water mixed with acidic vinegar into a jar of charcoal powder, then poured alkaline distilled water again.
Two types of distilled water were poured in, and after a while, water mixed with penicillin attached to the charcoal powder flowed down the jar.
The painter divided the penicillin concentrate into several vials and sealed the lids tightly.
‘The penicillin that came out first must have dissolved a lot, but the concentration of the last one must have thinned out, so I’m going to use it after experimenting.’
There was no need to have a concentrated solution with a weak concentration that did not kill staphylococci through experiments.
“Is this really a drug, Senator?”
Obo, who had been helping the fireman by his side, looked at the vials containing penicillin concentrate with a suspicious expression.
The painter made Obo work, but it was almost at the level of errands, and he deliberately did not teach the principle or method of extracting penicillin from green mold at all.
Of course, penicillin concentrate was just a drug, but not penicillin itself.
“Because it’s a medicine, I invested a lot of time to make it.”
“What the hell is good medicine for?”
“I’ll let you know later after treating patients who are fit for this drug.”
The painter had to carry out an experiment to kill staphylococci with this concentrate and also to encapsulate it, so he had to come back again to get materials.
But today, I wanted to stop here and rest.
In fact, while making the medicine, I continued to worry about whether it was okay to spread the secret recipe of this medicine to the world, and I came to my own conclusion.
The conclusion was that only he made and used this medicine and did not inform others.
—————————————
